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Narcolepsy Clinical Practice Insights and Educational Resources
Managing narcolepsy in clinical practice can be challenging.1,2 Know Narcolepsy is here to help.
Narcolepsy symptoms can have a significant impact, but may not always be obvious — even to the patient.1,3,4 Know Narcolepsy is an online resource that seeks to help healthcare professionals improve the lives of their patients with narcolepsy by offering insight into patient experiences, detailed information about the neurobiology of narcolepsy, as well as tools and resources for their practice.
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Exploring Histamine in Sleep-Wake State Stability
Dr. Thomas Scammell
Neurologist and sleep specialist
The Neurobiology of Normal Sleep and Wakefulness
The Pathophysiology of Narcolepsy
The Role of Histamine in Sleep and Wakefulness





Exploring Histamine in Sleep-Wake State Stability

The Neurobiology of Normal Sleep and Wakefulness

The Pathophysiology of Narcolepsy

The Role of Histamine in Sleep and Wakefulness
- American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014.
- Ahmed I, Thorpy M. Clinical features, diagnosis and treatment of narcolepsy. Clin Chest Med. 2010;31(2):371-381.
- Overeem S. The clinical features of cataplexy. In: Baumann CR, Bassetti CL, Scammell TE, eds. Narcolepsy: Pathophysiology, Diagnosis, and Treatment. Springer-Verlag New York; 2011:283-290.
- Ahmed IM, Thorpy MJ. Clinical evaluation of the patient with excessive sleepiness. In: Thorpy MJ, Billiard M, eds. Sleepiness: Causes, Consequences and Treatment. Cambridge University Press; 2011: 36-47.
- Haas HL, Sergeeva OA, Selbach O. Histamine in the nervous system. Physiol Rev. 2008;88(3):1183-1241.
- España RA, Scammell TE. Sleep neurobiology from a clinical perspective. Sleep. 2011;34(7):845-858.
- Schwartz JR, Roth T. Neurophysiology of sleep and wakefulness: basic science and clinical implications. Curr Neuropharmacol. 2008;6(4):367-378.
- Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Control of sleep and wakefulness. Physiol Rev. 2012;92(3):1087-1187.
- Scammell TE, Arrigoni E, Lipton JO. Neural circuitry of wakefulness and sleep. Neuron. 2017;93(4):747-765.
- Scammell TE. The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol. 2003;53(2):154-166.
- Shan L, Dauvilliers Y, Siegel JM. Interactions of the histamine and hypocretin systems in CNS disorders. Nat Rev Neurol. 2015;11(7):401-413.
- Scammell TE. Narcolepsy. N Engl J Med. 2015;373(27):2654-2662.